PostdocDepartment of Biomedical Engineering Graduate student [2007-2011]Graduate Group of Chemical Engineering and Materials Science PERSONAL EDUCATIONPh.D., Chemical Engineering, UC Davis, 2011 RESEARCHSingle-cell mechanics of phagocytosis. Movies below (sped up ~25-30 times) show experiments [Lee et al. 2011] and computer simulations [Herant et al. 2011] of neutrophil phagocytosis of a zymosan particle (1st and 3rd from left) and an antibody-coated bead (2nd and 4th from left). |
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PUBLICATIONS
2013. Mankovich, A.R., C.-Y. Lee, and V. Heinrich. Differential Effects of Serum Heat Treatment on Chemotaxis and Phagocytosis by Human Neutrophils. PLoS ONE 8(1): e54735. doi:10.1371/journal.pone.0054735 || PDF 907 KB
2011. Heinrich, V., and C.-Y. Lee. Blurred line between chemotactic chase and phagocytic consumption: An immunophysical, single-cell perspective. Journal of Cell Science 124(18):3041-3051. doi:10.1242/jcs.086413 || low-res. PDF 702 KB
2011. Lee, C.-Y., M. Herant, and V. Heinrich. Target-specific mechanics of phagocytosis: Protrusive neutrophil response to zymosan differs from the uptake of antibody-tagged pathogens. Journal of Cell Science 124(7):1106-1114. doi:10.1242/jcs.02876 || PDF 1104 KB
2011. Herant, M., C.-Y. Lee, M. Dembo, and V. Heinrich. Protrusive push versus enveloping embrace: Computational model of phagocytosis predicts key regulatory role of cytoskeletal membrane anchors. PLoS Computational Biology 7(1): e1001068. doi:10.1371/journal.pcbi.1001068 || PDF 274 KB
2008. Lee, C.-Y., J. Lam, and V. Heinrich. Quantitative comparison of the mechanistic phagocytic programs of neutrophils and macrophages. European Journal of Clinical Investigation 38(s1):62-63. doi:10.1111/j.1365-2362.2008.01926.x || PDF 78 KB
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CONFERENCE CONTRIBUTIONS
2012. 56th Annual Meeting of the Biophysical Society. Poster
2011. 6th Annual UC Davis Research Retreat on Host-Microbe Interactions. Poster
2011. 55th Annual Meeting of the Coccidioidomycosis Study Group. Poster and Co-author of Invited Lecture
2010. Biomedical Engineering Society Annual Meeting. Poster
2010. UC Systemwide Bioengineering Symposium. Poster
2009. Gordon Research Conference & Seminar: Phagocytes. Podium talk
2008. Biomedical Engineering Society Annual Meeting. Poster
2008. UC Systemwide Bioengineering Symposium. Podium talk
2008. Scientific Meeting of European Society for Clinical Investigation. Podium talk
2008. Biophysical Society Meeting. Poster
2007. UC Systemwide Bioengineering Symposium. Poster