Cheng-Yuk Lee


Department of Biomedical Engineering

Graduate student [2007-2011]

Graduate Group of Chemical Engineering and Materials Science


Ph.D., Chemical Engineering, UC Davis, 2011
B.S., Chemical Engineering, U. of Massachusetts – Amherst, 2006
B.S., Biochemistry and Molecular Biology, U. of Mass. – Amherst, 2006


Single-cell mechanics of phagocytosis.

Movies below (sped up ~25-30 times) show experiments [Lee et al. 2011] and computer simulations [Herant et al. 2011] of neutrophil phagocytosis of a zymosan particle (1st and 3rd from left) and an antibody-coated bead (2nd and 4th from left).

Phagocytosis_Zymosan_6050 Thumb_Phagocytosis_Zymosan_6050


2013. Mankovich, A.R., C.-Y. Lee, and V. Heinrich. Differential Effects of Serum Heat Treatment on Chemotaxis and Phagocytosis by Human Neutrophils. PLoS ONE 8(1): e54735. doi:10.1371/journal.pone.0054735 || PDF 907 KB

2011. Heinrich, V., and C.-Y. Lee. Blurred line between chemotactic chase and phagocytic consumption: An immunophysical, single-cell perspective. Journal of Cell Science 124(18):3041-3051. doi:10.1242/jcs.086413 || low-res. PDF 702 KB

2011. Lee, C.-Y., M. Herant, and V. Heinrich. Target-specific mechanics of phagocytosis: Protrusive neutrophil response to zymosan differs from the uptake of antibody-tagged pathogens. Journal of Cell Science 124(7):1106-1114. doi:10.1242/jcs.02876 || PDF 1104 KB

2011. Herant, M., C.-Y. Lee, M. Dembo, and V. Heinrich. Protrusive push versus enveloping embrace: Computational model of phagocytosis predicts key regulatory role of cytoskeletal membrane anchors. PLoS Computational Biology 7(1): e1001068. doi:10.1371/journal.pcbi.1001068 || PDF 274 KB

2008. Lee, C.-Y., J. Lam, and V. Heinrich. Quantitative comparison of the mechanistic phagocytic programs of neutrophils and macrophages. European Journal of Clinical Investigation 38(s1):62-63. doi:10.1111/j.1365-2362.2008.01926.x || PDF 78 KB



2012. 56th Annual Meeting of the Biophysical Society. Poster

2011. 6th Annual UC Davis Research Retreat on Host-Microbe Interactions. Poster

2011. 55th Annual Meeting of the Coccidioidomycosis Study Group. Poster and Co-author of Invited Lecture

2010. Biomedical Engineering Society Annual Meeting. Poster

2010. UC Systemwide Bioengineering Symposium. Poster

2009. Gordon Research Conference & Seminar: Phagocytes. Podium talk

2008. Biomedical Engineering Society Annual Meeting. Poster

2008. UC Systemwide Bioengineering Symposium. Podium talk

2008. Scientific Meeting of European Society for Clinical Investigation. Podium talk

2008. Biophysical Society Meeting. Poster

2007. UC Systemwide Bioengineering Symposium. Poster

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